Endocannabinoids are the molecules that act as chemical messengers that bind to cannabinoid cell receptors and tell the body to do certain things. The human body naturally produces endocannabinoids with the help of consuming foods like fatty acids found in nuts and fish. The 60 cannabinoid molecules found in cannabis also can bind to cannabinoid cell receptors and the corresponding molecules (agonists) in the human body. Although different cannabinoids (like CBD and THC cause different effects it is all through the same system that similar molecular messages are sent throughout the body. Put more simply, the molecules found in cannabis plants aid in the human body’s endocannabinoid system, which is responsible for many vital functions. The ECS system helps to regulate sleep, appetite, mood, motor control, immune function, pleasure, pain, reproduction and fertility, memory, and temperature regulation. When the ECS is in balance, one experiences homeostasis.
WHAT ARE THE SIDE EFFECTS OF CBD?
Multiple studies, published as early as 1980, suggest that CBD has minimal side effects and is safe for consumption. Nonetheless, consumers should be made aware of any known, potential drawbacks when consuming a product. Below, we discuss the findings from each recorded study and review on the safety and known side effects from CBD
Study in Pharmacology 1980
On January 3, 1980, Pharmacology published their findings conducted during a study in which they tested eight healthy volunteers and 15 patients with epilepsy, looking at the side effects of CBD when consumed daily for a month. Their reported conclusions were, ‘All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination.
International Journal of Neuroscience 1986
In 1986, oral doses, ranging from 100 to 600 mg per day of cannabidiol were given to 5 patients with dystonic movement disorders. In addition to recording specific benefits this study also uncovered mild side effects of CBD such as hypotension, dry mouth, psychomotor slowing, light-headedness, and sedation. It is also noteworthy that during this study two patients were given CBD in doses over 300 mg per day seemed to aggravate their Parkinson’s symptoms. Yet in 2014 a separate paper described how CBD significantly improves the lives of those with Parkinson disease.
Safety and side effects of Cannabidiol
Most recently in 2011, a review on the safety and side effects of cannabidiol, found that CBD might interfere with the hepatic drug metabolism, alteration of in vitro cell viability, decreased fertilization capacity or the reduced activity of p-glycoprotein. Have you ever been told by a doctor or pharmacist not to drink or eat grapefruit while taking a prescription medication? Grapefruit and CBD have a similar effect on P450, an enzyme found in the liver, which metabolizes different kinds of medications in the human body. If taken in large doses, CBD can inhibit the metabolizing properties of P450, temporarily neutralizing the effects of other medicinal products in the body’s system. This side effect is also responsible for why cannabidiol counteract the effects of THC
2006 Study Argentinian Study
In 2006 a group of scientists hypothesized that there are cannabinoid receptors in human’s salivary glands. In fact, their hypothesis was correct, which is most likely the reason that one of the previously discovered side effects of CBD is commonly known as cottonmouth. When CBD interacts with the endocannabinoid system, it inhibits the secretion of saliva, thus leaving some users with a dry sensation in their mouth.